IT'S
TIME to superCHARGE
YOUR cryo-EM
workflow.
Still waiting for job execution on the shared cluster? How about YOUR OWN mini-cluster in a box?
Cryo-electron microscopy (Cryo-EM) is an important research tool for structure biology and was chosen by Nature Methods as Methods of the Year 2015.
To solve 3D structures of proteins and macromolecules, a suite of sophisticated cryo-EM image-processing software tools need to be used, such as RELION from MRC Laboratory of Molecular Biology. Many of the intrinsic image processing steps could be dramatically sped up by GPU parallelization.
THE GPU revolution
With the introduction of GPU-accelerated RELION 2.0, the cryo-EM workflow can be significantly simplified. It is possible to achieve atomic resolution reconstruction on a single quad-GPU workstation within days and hours on a GPU cluster.
Significant speed-up is seen when compared to a similarly priced CPU node in the 2D and 3D classification steps (ref. DOI: 10.1101/059717).
3D Classification
Speedup: 40x
2D Classification
Speedup: 10x
OUR products
We offer GPU workstations as well as clusters optimized for cryo-EM workflow with a balance of performance and cost.
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Workstation Solutions Optimized for CryoEM
Note that customization is fully supported but may increase build time.
Intel i9
(8 to 18 cores)
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64GB ECC DDR4
(up to 128GB)
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2x NVIDIA RTX 2080Ti Graphics Cards with 11GB GDDR6
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480GB Enterprise SSD
6TB Enterprise HDD
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Recommended for developers and researchers with light load.
Mainstream
Workstation
Dual Intel Xeon Scalable
(8 cores at 2.10 GHz)
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128GB ECC DDR4
(up to 1TB)
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4x NVIDIA RTX 2080Ti Graphics Cards with 11GB GDDR6
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512GB SSD for boot
2x 480GB Enterprise SSD
3x 6TB Enterprise HDD
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Recommended for cryoEM researchers for routine use.
Dual Intel Xeon Scalable
(12 cores at 2.10 GHz)
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256GB ECC DDR4
(up to 1TB)
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4x NVIDIA RTX 2080Ti Graphics Cards with 11GB GDDR6
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512GB SSD for boot
2x 480GB Enterprise SSD
6x 6TB Enterprise HDD
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Recommended for power user working on large complexes.
Performance
Cluster Node
Dual Intel Xeon Scalable Gold
(14 cores)
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256GB ECC DDR4
(up to 1TB)
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4x GPUs in 1U
or
8x or 10x GPUs in 4U
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2x 480GB Enterprise SSD
Infiniband 56Gb
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Optimized for rackmount applications.
Developer
workstation
Performance
Workstation
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Cluster Solutions Optimized for CryoEM
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Computing
High GPU density
Easy cluster management with award-winning Bright Cluster Manager
Resource management with Slurm Workload Manager (multi-node RELION2 job submission with GPU support)
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Storage
Expand capacity without downtime up to 300 PB (petabyte)
Low TCO (total cost of ownership)
High sustained throughput with HDDs only
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Management
Flexibility to support mixed software versions
UNIQUE FEATURES
Enterprise quality
STABLE
Based on the cryo-EM use case, we optimize the build with enterprise quality parts, such as error-correcting code (ECC) memory and high-endurance Solid State Drives (SSDs).
Optimized for RELION 2.0
PROVEN
We work closely with the RELION developers to ensure compatibility of our hardware and benchmark every system to spec before shipping.
Peace of mind
WORRY FREE
Every system passes strict factory burn-in and comes with 3 year hardware warranty bundled with free software updates and friendly support from our team of cryoEM experts
Ready to run
SIMPLE SETUP
Pre-installed with cryoEM data processing tools, such as RELION, as well as public tutorial datasets. This way you can quickly put it to work on your SHINY STRUCTURE!
Asia, Europe, US
GLOBAL YET LOCAL
Manufacturing facilities in US, China and Germany to meet quality standards
Save a tree
EFFICIENT
A single GPU workstation or GPU cluster node can replace multiple traditional CPU cluster nodes, saving space and energy!
Trusted by leading cryo-EM labs
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ABOUT US
Single Particle, LLC is established to provide turn-key solutions and consulting for the growing cryo-EM community. Built by scientists with decades of combined experience in the field, Single Particle, LLC is striving to meet and exceed your expectations!
We work closely with selected hardware vendors with facilities in the US, China and Germany. Let us build you the next-gen GPU workstation or cluster!